Skip to content
Basenji Forums
  1. Home
  2. Basenji Health Issues & Questions
  3. Fanconi Disease

Fanconi Disease

Basenji Health Issues & Questions

Suggested Topics

  • D

    Cushings Disease

    Basenji Health Issues & Questions
    3
    0 Votes
    3 Posts
    3k Views
    D
    Here is the test information that Missy had done and an article with the portion that includes Melatonin for treatment. I have inlcuded the webpage for the entire article. She has not been on the Melatonin long and I am slowly increasing her dosage but she is definitely not as puffy in the intestinal area as she was. The Adrenal Panel with Combined Dex Supp/ACTH Stim Test for Dogs: The following hormones are tested in the adrenal panel: Cortisol, Estradiol, Androstenedione, 17-Hydroxyprogesterone, Progesterone and Aldosterone. REVIEW ARTICLES Steroid Profiles in the Diagnosis of Canine Adrenal Disorders Jack W. Oliver, Proceedings 25th ACVIM Forum, Pp. 471-473, Seattle, WA. 2007. http://www.vet.utk.edu/diagnostic/endocrinology/pdf/Steroids%20Profiles%20in%20the%20Diagnosis%20of%20.doc Melatonin. Results of in vitro cell culture (human H295R adrenocortical carcinoma cells) studies in our lab55 revealed that both 21-hydroxylase and aromatase enzymes were inhibited by melatonin. Also, in dogs with adrenal disease that are treated with melatonin, and repeat adrenal steroid panels are done, cortisol levels are consistently reduced, and estradiol levels are variably reduced.29 Inhibition of the 21-hydroxylase enzyme would lower cortisol levels, and inhibition of the aromatase enzyme would lower estradiol levels. Estradiol levels were decreased in a prior study of dogs treated with melatonin.31 Results of in vitro studies with human MCF-7 breast cancer cells also revealed that melatonin inhibited aromatase enzyme, which resulted in reduced estradiol levels.56 Melatonin treatment for cases of mild adrenal disease in dogs may be effective, and particularly in cases where sex steroids are increased. Jennifer
  • barklessk9B

    Fanconi Testing

    Basenji Health Issues & Questions
    6
    0 Votes
    6 Posts
    5k Views
    S
    We hope the results are good, and we will cheer if they are, and if they aren't, we will support you. Do let us know what you have found please.
  • irenaI

    Fanconi resutls

    Basenji Health Issues & Questions
    2
    0 Votes
    2 Posts
    2k Views
    tanzaT
    Congrats on your results….
  • BenkuraB

    My Fanconi Results

    Basenji Health Issues & Questions
    18
    0 Votes
    18 Posts
    8k Views
    BenkuraB
    @lukris: That's good news about Chance Vicky. At least you know you have to find a nice clear boy for Nakura now. You must be relieved. Chance is Nakura's son so can't use him! The search continues. We need to encourage more people to test are there are only about 6 clear stud dogs in UK at moment. So not much too choose from there!!
  • etzbsederE

    Fanconi Test

    Basenji Health Issues & Questions
    4
    0 Votes
    4 Posts
    4k Views
    QuercusQ
    @etzbseder: Thanks, I've seen that before, but forgot about it. After looking at that, it shows that my answer would be: Clear pups ONLY means that neither parent is affected, and that does not change with multiple clear pups. The only thing that shows any determination of the parents is a test of the parent themselves (or if their grandparents are clear). correct. The more clear pups (with no affecteds or carriers) you had from the breeding of the same two animals, the more LIKELY it is that the parents are clear…but it certainly would not be a for sure.
  • PongoGirlP

    Cushings Disease :(

    Basenji Health Issues & Questions
    13
    0 Votes
    13 Posts
    11k Views
    tanzaT
    @MaxBooBooBear: Yes–I was trained how to do it--and did do it at home a couple of times, but it was really a struggle for me. Both my dogs reacted very, very poorly to the procedure--and it really took two people to do it comfortably. Since I live alone, it was best for me to go have it done at my vets who is only about 5 minutes from me. They also got a special contraption for the bag of fluids that expressed the fluid out so it went much more quickly. But I know many people who are able to do it at home because their dogs or cats are more tolerant than mine were. It's much cheaper that way :) One of the best ways is to have a grooming table that comes complete with a "noose"…. It supports the head and keeps them standing.... you can fairly easily hang the IV bag off the same support.... while I agree the first couple of times it helps to have two, one to hold the dog, one to "stick" the needle in.... but once you get the hang of it.. it usually works.... But whatever works... and that is great that you could just run down to your Vet...