Skip to content

Fanconi Disease

Basenji Health Issues & Questions
  • The venous blood gases - they take blood from the dog and use a special analysis machine to determine the pH, the 'base excess', and several other blood chemistries. I don't pretend to know what they all mean, but I know what the important values are from experience and from reading the protocol. (Linda, maybe you can enlighten us more?) It takes a special machine to read this and not all vets have them. Many vet specialty groups do and so do some vet emergency clinics - in some areas, it has to be done at a people hospital. The machine is called an I-STAT. The blood gases are done after a diagnosis of Fanconi, which is made by finding sugar in the urine and normal or even low blood glucose in a regular blood panel.
    The sugary urine is usually the first symptom - even a trace amount of sugar in the urine is NEVER a good thing. That's why we strip test monthly, to see if the dog is spilling sugar.
    The UTIs have to be watched for in a dog with Fanconi. As I said, they frequently don't show up on urinanalysis; most of us with Fanconi dogs go by symptoms - depressed appetite, "accidents" or night leakage, general lethargy, and sometimes pain in the back or back legs. When we see these symptoms, we have the vet give us a 2 -3 week course of antibiotics (usually Clavamox or Baytril) even if the urinanalysis doesn't show an infection. There are some Fanconi dogs that are so prone to these hidden UTIs that they have been placed on 'pulse therapy' with a couple of weeks on antibiotics on a regular basis.
    Hope this explains things better…there is a group for owners of Fanconi dogs, and there are people on there with much more knowledge than I have. Should any of you ever have to deal with this, it's a fabulous resource and a terrific support system.

    I know this was long, sorry!

  • To me, this test is painless to the dogs, cheap to do, so, why not do it.
    We do it the first of each month.
    Any change in the dipstick, and the dogs are off to the vet.
    This is something that can crop up in other breeds of dogs.
    So, why not do it?

  • Terry, it's not too long . . . I appreciate your time to explain the testing procedure of VBG so I am familiarized for if and/or when I need to make sure proper testing is done for Duke. Thank you, as I seek responsibility in educating myself. I have opened a folder for Basenji Medical Care so I have reference as needed. An excellent question to ask a prospective vet is if they have a resource to an I-STAT machine for fanconi. If he doesn't know - then find one who does. Your explaination has helped me understand much better. You've also pointed out some of the symptoms to observe for fanconi. Thank you.

  • I am a new B owner. What is Fanconi? What are the symptoms?
    At what age should I start testing my B? She is 1year 2 mos.
    Any info on this would be appreciated. I want to make sure Maggie lives a long and happy life.

    tHANKS

  • I am sad to read your post.
    The breeder you got your dog from should have given you info on fanconis and any fanconis that runs in their line…
    Who did you get your b from?
    Fanconis is a kidney issue b's and even humans have.
    The dogs drink vast amounts of water and flush all the chemicals they need to live, out in their pee.
    Get some test strips, for humans spilling sugar, and put the strip under the dogs pee, or on the dogs privates right after they pee. Its not expensive, about $10 a jar...go to Walgreens or a drug store and ask. There are a few different brands...
    If the strips change color, then you need to get to the vet and get your basenji on the fanconis protocal asap.
    Its a bunch of pills you give the dog every day to keep the dogs body running properly.
    At this time, there is no cure for fanconis...just treatment that slows the damage to the dogs kidneys down...but it is progressive and will shorten your b's life.
    The person you got the dog from should have been upfront with you re this.
    My advice is to phone them and find out how many dogs in their line have had this crop up.
    If they say never, then I would not think they are being truthful.
    I have seen wonderful breeders who do everything right, have this crop up.
    BUT they stack the deck in favor of the dogs they breed and they tell the buyers what is happening.
    Good luck.
    I know of some wonderful fanconis support lists to suggest if this crops up in your basenji.
    STRIP TEST every month! the first of every month is when we do it.
    THe sooner you find out, the sooner you can slow the damage to your dogs kidneys.

  • O.k this is scary. I got my dog from a shelter and according to them he's a pure breed B so are there any signs or symptoms to this disease?

  • Thanks there's nothing like knowing as much as you can to keep your baby safe

  • The links that were recommended are all good but I would like to focus on one small piece of something that you can do right now - test your dogs urine - you can get test strips from the diabetic section of walmart, target drugs stores etc. I would test daily for at least a week - and then test on a regular basis - like monthly - that one thing can alert you before they become symptomatic and drink and pee a lot. With early detection - even if your dog does eventually have it - by following the information and protocols in those website - you can enjoy a long life together.

  • I would also add that everyone should test maybe for 4 or 5 days in a row each month… I know that when a friend of mine's Basenji started spilling, one day it showed positive, next day did not, then two days later was positive again... and he was Fanconi afflicted...
    Remember the test strips are only good for about 6 months.. so you might as well get the most use out of them..

  • @Terry:

    I believe she should still be tested. First of all, Basenjis are not the only breed to get Fanconi. On the Fanconi List, we have had German Shepherds, Bichons, Westies, Cocker Spaniels, a Chinese Crested and even a cat!

    Don't forget Nowegian Elkhounds!

  • As the test is easy and doesn't hurt the dog, why not test them all?

  • @sharronhurlbut:

    As the test is easy and doesn't hurt the dog, why not test them all?

    Exactly… and hopefully before the end of the summer we will have a test for Fanconi....

Suggested Topics

  • Cushings Disease

    Basenji Health Issues & Questions
    2
    0 Votes
    2 Posts
    653 Views
    B
    Yes, my Naomi had Cushing’s. You will need to work with your veterinarian for the best treatment. Lysodren was the first drug we tried. Trilostane was the drug that really worked for her. She regained her muscle tone and she strength and brightened back up. She did very well. She had her ACTH tested regularly, sitting quietly and patiently in the waiting room with me as she never liked the kennels at the veterinarian’s and threw unending basenji fits. I do remember the first signs of Cushing’s. Naomi’s tail developed a strange kink. None of the veterinarians in the practice could find anything wrong with her tail. She was otherwise healthy and bright. Next, she dropped a bar in agility. She never touched a jump before that, and could of course, jump much higher than her designated jump height. It did take a while for her to get to the point where she could be diagnosed. Naomi fought inflammatory bowel syndrome for a good part of her life. She often had bad tummy days. We did the best we could to keep her comfortable and happy. In the end, a tumor was detected in her bowel, and we made the difficult decision to euthanize. I don’t know how long she would have lived on the Trilostane protocol. She was a darling, beautiful little dog, and I miss her greatly. I do wish you the greatest of luck with your baby, and pray that your sweet pup and you have many, happy, healthy years ahead of you.
  • Cushings Disease

    Basenji Health Issues & Questions
    3
    0 Votes
    3 Posts
    2k Views
    D
    Here is the test information that Missy had done and an article with the portion that includes Melatonin for treatment. I have inlcuded the webpage for the entire article. She has not been on the Melatonin long and I am slowly increasing her dosage but she is definitely not as puffy in the intestinal area as she was. The Adrenal Panel with Combined Dex Supp/ACTH Stim Test for Dogs: The following hormones are tested in the adrenal panel: Cortisol, Estradiol, Androstenedione, 17-Hydroxyprogesterone, Progesterone and Aldosterone. REVIEW ARTICLES Steroid Profiles in the Diagnosis of Canine Adrenal Disorders Jack W. Oliver, Proceedings 25th ACVIM Forum, Pp. 471-473, Seattle, WA. 2007. http://www.vet.utk.edu/diagnostic/endocrinology/pdf/Steroids%20Profiles%20in%20the%20Diagnosis%20of%20.doc Melatonin. Results of in vitro cell culture (human H295R adrenocortical carcinoma cells) studies in our lab55 revealed that both 21-hydroxylase and aromatase enzymes were inhibited by melatonin. Also, in dogs with adrenal disease that are treated with melatonin, and repeat adrenal steroid panels are done, cortisol levels are consistently reduced, and estradiol levels are variably reduced.29 Inhibition of the 21-hydroxylase enzyme would lower cortisol levels, and inhibition of the aromatase enzyme would lower estradiol levels. Estradiol levels were decreased in a prior study of dogs treated with melatonin.31 Results of in vitro studies with human MCF-7 breast cancer cells also revealed that melatonin inhibited aromatase enzyme, which resulted in reduced estradiol levels.56 Melatonin treatment for cases of mild adrenal disease in dogs may be effective, and particularly in cases where sex steroids are increased. Jennifer
  • Fanconi Test

    Basenji Health Issues & Questions
    4
    0 Votes
    4 Posts
    2k Views
    QuercusQ
    @etzbseder: Thanks, I've seen that before, but forgot about it. After looking at that, it shows that my answer would be: Clear pups ONLY means that neither parent is affected, and that does not change with multiple clear pups. The only thing that shows any determination of the parents is a test of the parent themselves (or if their grandparents are clear). correct. The more clear pups (with no affecteds or carriers) you had from the breeding of the same two animals, the more LIKELY it is that the parents are clear…but it certainly would not be a for sure.
  • Disease

    Basenji Health Issues & Questions
    11
    0 Votes
    11 Posts
    4k Views
    Ninabeana26N
    Yea my vet told me that during our last appointment. He said not to let Dallas sniff other dogs poop no matter where we are because the poop can contain diseases. I see poop all around our community because people don't pick it up after their dogs but Dallas [so far] never really gets too near ti that I have to pull him away.
  • Fanconi Question

    Basenji Health Issues & Questions
    5
    0 Votes
    5 Posts
    3k Views
    E
    Thank you for all the information. I am going to a dog show in Springfield, Illinois next weekend to meet some dogs from Meiterhaus (Tad Brooks). This makes me feel alot more comfortable. :D
  • Cushings Disease :(

    Basenji Health Issues & Questions
    13
    0 Votes
    13 Posts
    8k Views
    tanzaT
    @MaxBooBooBear: Yes–I was trained how to do it--and did do it at home a couple of times, but it was really a struggle for me. Both my dogs reacted very, very poorly to the procedure--and it really took two people to do it comfortably. Since I live alone, it was best for me to go have it done at my vets who is only about 5 minutes from me. They also got a special contraption for the bag of fluids that expressed the fluid out so it went much more quickly. But I know many people who are able to do it at home because their dogs or cats are more tolerant than mine were. It's much cheaper that way :) One of the best ways is to have a grooming table that comes complete with a "noose"…. It supports the head and keeps them standing.... you can fairly easily hang the IV bag off the same support.... while I agree the first couple of times it helps to have two, one to hold the dog, one to "stick" the needle in.... but once you get the hang of it.. it usually works.... But whatever works... and that is great that you could just run down to your Vet...