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Fanconi Disease

Basenji Health Issues & Questions

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  • Cushings Disease

    Basenji Health Issues & Questions
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    tanzaT
    @gwen - It is not common Basenjis, many breeds, mixed breeds have/develop Cushings.
  • Cushings Disease

    Basenji Health Issues & Questions
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    B
    Yes, my Naomi had Cushing’s. You will need to work with your veterinarian for the best treatment. Lysodren was the first drug we tried. Trilostane was the drug that really worked for her. She regained her muscle tone and she strength and brightened back up. She did very well. She had her ACTH tested regularly, sitting quietly and patiently in the waiting room with me as she never liked the kennels at the veterinarian’s and threw unending basenji fits. I do remember the first signs of Cushing’s. Naomi’s tail developed a strange kink. None of the veterinarians in the practice could find anything wrong with her tail. She was otherwise healthy and bright. Next, she dropped a bar in agility. She never touched a jump before that, and could of course, jump much higher than her designated jump height. It did take a while for her to get to the point where she could be diagnosed. Naomi fought inflammatory bowel syndrome for a good part of her life. She often had bad tummy days. We did the best we could to keep her comfortable and happy. In the end, a tumor was detected in her bowel, and we made the difficult decision to euthanize. I don’t know how long she would have lived on the Trilostane protocol. She was a darling, beautiful little dog, and I miss her greatly. I do wish you the greatest of luck with your baby, and pray that your sweet pup and you have many, happy, healthy years ahead of you.
  • Cushings Disease

    Basenji Health Issues & Questions
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    D
    Here is the test information that Missy had done and an article with the portion that includes Melatonin for treatment. I have inlcuded the webpage for the entire article. She has not been on the Melatonin long and I am slowly increasing her dosage but she is definitely not as puffy in the intestinal area as she was. The Adrenal Panel with Combined Dex Supp/ACTH Stim Test for Dogs: The following hormones are tested in the adrenal panel: Cortisol, Estradiol, Androstenedione, 17-Hydroxyprogesterone, Progesterone and Aldosterone. REVIEW ARTICLES Steroid Profiles in the Diagnosis of Canine Adrenal Disorders Jack W. Oliver, Proceedings 25th ACVIM Forum, Pp. 471-473, Seattle, WA. 2007. http://www.vet.utk.edu/diagnostic/endocrinology/pdf/Steroids%20Profiles%20in%20the%20Diagnosis%20of%20.doc Melatonin. Results of in vitro cell culture (human H295R adrenocortical carcinoma cells) studies in our lab55 revealed that both 21-hydroxylase and aromatase enzymes were inhibited by melatonin. Also, in dogs with adrenal disease that are treated with melatonin, and repeat adrenal steroid panels are done, cortisol levels are consistently reduced, and estradiol levels are variably reduced.29 Inhibition of the 21-hydroxylase enzyme would lower cortisol levels, and inhibition of the aromatase enzyme would lower estradiol levels. Estradiol levels were decreased in a prior study of dogs treated with melatonin.31 Results of in vitro studies with human MCF-7 breast cancer cells also revealed that melatonin inhibited aromatase enzyme, which resulted in reduced estradiol levels.56 Melatonin treatment for cases of mild adrenal disease in dogs may be effective, and particularly in cases where sex steroids are increased. Jennifer
  • Luna has Fancony

    Basenji Health Issues & Questions
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    khanisK
    If you want to email me off the boards… bennyburnerbono at aol.com I have tons of information regarding living with Fanconi and treating your Basenji. I have been there quite a few times... and with perseverance, you will get through it!
  • Fanconi Question

    Basenji Health Issues & Questions
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    E
    Thank you for all the information. I am going to a dog show in Springfield, Illinois next weekend to meet some dogs from Meiterhaus (Tad Brooks). This makes me feel alot more comfortable. :D
  • Monkey has Fanconi :(

    Basenji Health Issues & Questions
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    DukeD
    @tanza: If you go to www.basenji.org, you can get information about Fanconi from Dr. Gonto that developed the protocol. Best to print it off and take it with you tomorrow… and good luck.... I believe you should print the information about Dr. Gonto's protocal and give the information to your vet. Your vet can follow Dr. Gonto's treatment program, i.e. lab tests to run; follow-up lab suggestions; therapeutic goals; management dosing guidelines, etc. Your vet should read all the information. There is also also correspondence info: address, email and phone/fax numbers to reach Dr. Gonto. So sorry for you and your baby. Good luck with your visit tomorrow. I would go in armed with this information.