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Fanconi Disease

Basenji Health Issues & Questions

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  • Fanconi Syndrome

    Basenji Health Issues & Questions
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    DebraDownSouthD
    Any update ?
  • Cushings Disease

    Basenji Health Issues & Questions
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    D
    Here is the test information that Missy had done and an article with the portion that includes Melatonin for treatment. I have inlcuded the webpage for the entire article. She has not been on the Melatonin long and I am slowly increasing her dosage but she is definitely not as puffy in the intestinal area as she was. The Adrenal Panel with Combined Dex Supp/ACTH Stim Test for Dogs: The following hormones are tested in the adrenal panel: Cortisol, Estradiol, Androstenedione, 17-Hydroxyprogesterone, Progesterone and Aldosterone. REVIEW ARTICLES Steroid Profiles in the Diagnosis of Canine Adrenal Disorders Jack W. Oliver, Proceedings 25th ACVIM Forum, Pp. 471-473, Seattle, WA. 2007. http://www.vet.utk.edu/diagnostic/endocrinology/pdf/Steroids%20Profiles%20in%20the%20Diagnosis%20of%20.doc Melatonin. Results of in vitro cell culture (human H295R adrenocortical carcinoma cells) studies in our lab55 revealed that both 21-hydroxylase and aromatase enzymes were inhibited by melatonin. Also, in dogs with adrenal disease that are treated with melatonin, and repeat adrenal steroid panels are done, cortisol levels are consistently reduced, and estradiol levels are variably reduced.29 Inhibition of the 21-hydroxylase enzyme would lower cortisol levels, and inhibition of the aromatase enzyme would lower estradiol levels. Estradiol levels were decreased in a prior study of dogs treated with melatonin.31 Results of in vitro studies with human MCF-7 breast cancer cells also revealed that melatonin inhibited aromatase enzyme, which resulted in reduced estradiol levels.56 Melatonin treatment for cases of mild adrenal disease in dogs may be effective, and particularly in cases where sex steroids are increased. Jennifer
  • My Haley has Fanconi…........

    Basenji Health Issues & Questions
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    P
    hi there sorry to hear this but , im going through the same thing right now but my boy hasnt started showing signs yet but he tested carrier/affected, but DR.GONTO WILL TAKE THE TIME TO TALK TO YOU AND THE VETS HE IS A REAL HERO ! I HAVE TALKED TO HIM A FEW TIMES. I'M GOING TO BE EMAILING HIM THIS WEEK WITH MY BOYS VEROUS BLOOD GASSES WORK RESAULTS TO SEE WHAT NEEDS TO BE DONE ON HIS FOOD OR MEDICATIONS IF ANY YET!!. AS IM KEEPING MY FINGURS CROSSED! MY BOY'S 3 NOW AND I GOT HIM TEST THANKS TO TANZA AND IVOSS THERE THE ONES THAT HAVE HELPED ME OUT OH, WAIT SHARRONHULSBUT TOO!. THERE GREAT TO TALK TOO AND GET ADVISE FROM. AGAIN SORRY TO HEAR ABOUT YOUR BABY BASENJI, AND GOOD LUCK WITH EVERYTHING.!
  • Fanconi Results

    Basenji Health Issues & Questions
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    P
    congratulation kathy. that's really great to hear. i hope my boy will be clear too!!. by the way how idi you get his ggg grandpa's resault last time i talked to u??>
  • Fanconi Test

    Basenji Health Issues & Questions
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    QuercusQ
    @etzbseder: Thanks, I've seen that before, but forgot about it. After looking at that, it shows that my answer would be: Clear pups ONLY means that neither parent is affected, and that does not change with multiple clear pups. The only thing that shows any determination of the parents is a test of the parent themselves (or if their grandparents are clear). correct. The more clear pups (with no affecteds or carriers) you had from the breeding of the same two animals, the more LIKELY it is that the parents are clear…but it certainly would not be a for sure.
  • Monkey has Fanconi :(

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    DukeD
    @tanza: If you go to www.basenji.org, you can get information about Fanconi from Dr. Gonto that developed the protocol. Best to print it off and take it with you tomorrow… and good luck.... I believe you should print the information about Dr. Gonto's protocal and give the information to your vet. Your vet can follow Dr. Gonto's treatment program, i.e. lab tests to run; follow-up lab suggestions; therapeutic goals; management dosing guidelines, etc. Your vet should read all the information. There is also also correspondence info: address, email and phone/fax numbers to reach Dr. Gonto. So sorry for you and your baby. Good luck with your visit tomorrow. I would go in armed with this information.