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Fanconi Disease

Basenji Health Issues & Questions

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  • Cushings Disease

    Basenji Health Issues & Questions
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    D
    Here is the test information that Missy had done and an article with the portion that includes Melatonin for treatment. I have inlcuded the webpage for the entire article. She has not been on the Melatonin long and I am slowly increasing her dosage but she is definitely not as puffy in the intestinal area as she was. The Adrenal Panel with Combined Dex Supp/ACTH Stim Test for Dogs: The following hormones are tested in the adrenal panel: Cortisol, Estradiol, Androstenedione, 17-Hydroxyprogesterone, Progesterone and Aldosterone. REVIEW ARTICLES Steroid Profiles in the Diagnosis of Canine Adrenal Disorders Jack W. Oliver, Proceedings 25th ACVIM Forum, Pp. 471-473, Seattle, WA. 2007. http://www.vet.utk.edu/diagnostic/endocrinology/pdf/Steroids%20Profiles%20in%20the%20Diagnosis%20of%20.doc Melatonin. Results of in vitro cell culture (human H295R adrenocortical carcinoma cells) studies in our lab55 revealed that both 21-hydroxylase and aromatase enzymes were inhibited by melatonin. Also, in dogs with adrenal disease that are treated with melatonin, and repeat adrenal steroid panels are done, cortisol levels are consistently reduced, and estradiol levels are variably reduced.29 Inhibition of the 21-hydroxylase enzyme would lower cortisol levels, and inhibition of the aromatase enzyme would lower estradiol levels. Estradiol levels were decreased in a prior study of dogs treated with melatonin.31 Results of in vitro studies with human MCF-7 breast cancer cells also revealed that melatonin inhibited aromatase enzyme, which resulted in reduced estradiol levels.56 Melatonin treatment for cases of mild adrenal disease in dogs may be effective, and particularly in cases where sex steroids are increased. Jennifer
  • Fanconi resutls

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    tanzaT
    Congrats on your results….
  • Fanconi Results

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    BenkuraB
    That's great news. I bet you're glad the waiting is over. :)
  • Disease

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    Ninabeana26N
    Yea my vet told me that during our last appointment. He said not to let Dallas sniff other dogs poop no matter where we are because the poop can contain diseases. I see poop all around our community because people don't pick it up after their dogs but Dallas [so far] never really gets too near ti that I have to pull him away.
  • Fanconi Testing

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    tanzaT
    @dmcarty: re: puppy mills and testing only one parent - I know for a FACT that at one place the sire of several years of litters was not the sire - it was a male who had good papers so his name was listed even though he was DEAD. One of the PM's males was the sire of several litters attributed to this OTHER dog. (I happen to know the person who owned the substitute sire) So it is unfortunate but the testing will only be as ethical as those who provide information to the test. Geez I hate to even say that but I am afraid that it's true. No doubt about that… and another reason to only look at AKC who has a DNA parentage program for high volume breeders...
  • Monkey has Fanconi :(

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    DukeD
    @tanza: If you go to www.basenji.org, you can get information about Fanconi from Dr. Gonto that developed the protocol. Best to print it off and take it with you tomorrow… and good luck.... I believe you should print the information about Dr. Gonto's protocal and give the information to your vet. Your vet can follow Dr. Gonto's treatment program, i.e. lab tests to run; follow-up lab suggestions; therapeutic goals; management dosing guidelines, etc. Your vet should read all the information. There is also also correspondence info: address, email and phone/fax numbers to reach Dr. Gonto. So sorry for you and your baby. Good luck with your visit tomorrow. I would go in armed with this information.