If sib is "clear" do I need to test brother?

[kiroja]

@NicholasDenis:

So if a breeder breeds probable clear dogs it is possible to have a affected puppy in that litter?

Yes.

If at least one PARENT is clear, then NO puppies should be affected. The worst they would be is a carrier. But if a PUPPY is clear, and parents are untested, then that's another story.

Puppies can be affected if both parents are carriers or affecteds. (or indeterminates, which are considered carriers at this time)

The example they are referring to is when a carrier is bred to another carrier. This mating can produce clear offspring, as well as carriers or affecteds. So the whole spectrum. That is why it is not safe when a littermate is clear, because another littermate could be affected.

A carrier doesn't get sick, but it has both a "normal" gene and a "bad" gene. If the puppy gets the normal gene from both parents, it's clear. If it gets the bad gene from both parents, it's affected. If it gets a normal from one parent and a bad from the other, then it becomes a carrier too.

The only scenario where you could get a clear puppy in the same litter as an affected puppy is when two carriers are bred together. But that is unfortunately a very common scenario, especially with people who don't do the DNA test and only rely on the urine test or no test at all.

[lvoss]

For those who are visual learners, you can check out this page for some charts on what you can expect from different breedings. You cannot get Affected puppies if one parent is Clear.

http://www.geocities.com/rugosab/FanconiTestPage.htm

[Basenjimamma]

Thanks Ivoss, that helped. I knew I had already seen that diagram, but couldn't remember where.
I see that my Otis is "safe", both of his parents tested probable clear/normal. I will test him anyway to have him in the system, just haven't gotten to it yet.

Petra

[morgansc]

I'm hapy to report that Chacho's fanconi test came back clear/normal. That was good news.

[Basenjimamma]

Awesome news, congrats.

[basi]

Great news:D

[Patty]

Mutation can occur at any time! There is never a guarantee only a probability.

However mutation is a rare occurrence so don't panic anyone!

[ibi_n_sane]

fantastic results, congrats!

[CrazyBasenjiMom]

A whole new world has opened up to me since I joinned this forum and learning to navaigate it.

I 've had my Belle since she was 8 weeks old, no history on her parents…she is wonderful. Getting to know this breed has been quit a journey.
Now I have two rescure B's, brothers , no history, and they are my forever dogs now!:)

They were in poor condition when I got them, 10 weeks ago, I've got their skin condition's healed and under controll....weight gain, happy campers now.

Sooooo, testing....what do I need to get, to do the test myself or is the vet the best way.

Anything you can tell me, there is a wealth of experience out here and I need to learn more now that I have this pack.

I love this breed, they match my personality..... to

Let moi know,

Baroooos & toe kisses form the Hart Pack, Belle, Ra & Shango:)

[morgansc]

Hi

You can download information you need at: http://www.basenjihealth.org/linkage-faq.html. I purchased the test online, they sent the kit (it is very easy to obtain the sample-it is a saliva sample), I sent it to them, and I got results in about four weeks.

Hope that helps. Looks as though you have your hands full. I agree with you; basenjis are the only breed.

[Basenjimamma]

Cindy,
I did the same thing. Go online, get the kits in the mail, take the test (easy check swab) in the AM, before food has been given, careful not to touch the test with your hands, send it off and wait a week or two for answers, that by the way is the hardest, the wait.. Very easy to do, and painless for the dog..

By the way, as far as doing both Ra and Shango, I would do it as you do not know about their parents.

[CrazyBasenjiMom]

Thanks,

Geez, this is like some of my friends waiting on there AIDS testing…..I'll order soon. Lets try and set a play date next week Tuesday and Thursdays are good for me

Later

[Basenjimamma]

Either day is good for me as well. Let's see how the weather is supposed to be, maybe we will get that cool front they were talking about..

[sharronhurlbut]

Knowing what to expect is so wonderful..if the dog is clear or a carrier, then its a weight off your mind, if its affected, then you know how to educate yourself to get ready for what might happen.
Do let us know.
We will be there for you.

[jules]

how can one family of basenjis have the majority of them come back indeterminate? this puzzles me as one did come back affected

[EskiLovr]

I have some knowledge of genetics, and I can explain a little about the 'indeterminate' finding. Fanconi is not a single loci disorder. Multiple genes in several locations are involved in a 'probably affected' result. 'Indeterminate' results usually carry affected type results in some of the locations, but not all of them.

Hope this helps

[lvoss]

That is not correct, Fanconi is believed to be a single locus disorder but the locus has not been precisely indentified at this time. The current test is not testing for the actual gene which has not yet been discovered but instead uses three markers that are a located in close proximity to the gene. When 1 or more of these markers separates from the others due to crossing over during Prophase I of meiosis there is no way to tell which markers the gene went with.

[EskiLovr]

Then where does the "indeterminate" result come from?

[lvoss]

The "interdeterminate" result comes when a dog has inherited an incomplete set of markers. When this happens there is no way to know whether they have the inherited the gene with the partial set of markers or not so they are labeled "indeterminate".

[jules]

im still confused, how can you have indeterminate between clear and carrier but not between carrier and affected and why does a lot of family members come back as indeterminate between clear and carrieri could understand if it was only one or two but it is most of them