Major behavior change after 10 years!! Help!

[DebraDownSouth]

Rocky1, I am sorry about your dog, and absolutely liver is a KNOWN side effect, albeit small, with the drug. So anyone doubting you needs to do some research.

However, your other information is a not accurate.

first, no, clomicalm is not the doggy form of prozac.

Second, 5-htp has toxicity also. Almost no drug comes without risks. http://www.ncbi.nlm.nih.gov/pubmed/10863592
Add to the fact that prozac has been used and researched heavily, whereas research on 5-HTP is scarce in humans and almost nonexistent in dogs beyond the toxicity above. "natural" doesn't mean safe.
http://psychology.wikia.com/wiki/Hydroxytryptophan_(5-)

In humans it also can cause liver damage

Tryptophan use has been associated with the development of serious conditions, such as liver and brain toxicity, and with eosinophilic myalgia syndrome (EMS), a potentially fatal disorder that affects the skin, blood, muscles, and organs (see "Overview" section). Such reports prompted the FDA to ban the sale of all tryptophan supplements in 1989. As with tryptophan, EMS has been reported in 10 people taking 5-HTP.
Side effects of 5-HTP are generally mild and may include nausea, heartburn, gas, feelings of fullness, and rumbling sensations in some people. At high doses, serotonin syndrome, a dangerous condition caused by too much serotonin in the body, could develop. Talk to your health care provider before taking higher-than-recommended doses.
People with high blood pressure or diabetes should talk to their doctor before taking 5-HTP.
If you take antidepressants, you should not take 5-HTP (see "Possible Interactions" section).
People with liver disease, pregnant women, and women who are breastfeeding should not take 5-HTP.<<

Clomicalm (clomipramine hydrochloride) is a tricyclic antidepressant and affects chemicals in the brain (serotonin)
Prozac, fluoxetine, is a selective serotonin reuptake inhibitor (SSRI) antidepressant drug . Its FDA-approved veterinary formulation is known as Reconcile.

Clomicalm slows the reabsorption rate of the neurotransmitters serotonin and norepinephrine, allowing their levels to rise in the brain. This drug is mainly used to treat separation anxiety. Prozac, on the other hand, works by strongly blocking the reabsorption of serotonin allowing more serotonin to be available for extended periods of time.
http://www.ehow.com/info_12227764_difference-between-clomicalm-prozac-dogs.html

http://www.ncbi.nlm.nih.gov/pubmed/10863592

Prozac, clomicalm and 5-HTP can all cause liver issues.

[DebraDownSouth]

@spetro14 said in Major behavior change after 10 years!! Help!:

Joey has been crate free while I am gone for 10 years. We moved from a house to an apartment 2 years ago while our house is being built. He has been fine until about 1 month ago.>

The first thing I would do is a full blood panel, especially thyroid, and make sure all is okay. Also, hearing and visual test. If he had begun when you moved, the move would make sense, but 2 yrs in... something else is going on.

I know it may sound crazy, but there is very firm research behind thundershirts. http://www.thundershirt.com/faq
Both of my basenjis responded very positively to them.

Failing all else, there are indestructible crates that they cannot damage teeth or get out of. But I am hoping you can figure out what is up and fix the problem.

[spetro14]

Thank you all for your input! I don't feel as alone in trying to solve this.
I am considering a thundershirt but am concerned he will tear it off himself. He has done so with a pheromone collar I tried.
Yes I want my dog to be around for some time to come but quality of life plays an important role as well.
I plan to meet with a behavioral therapist too.
I am considering a thundershirt but am concerned that he will tear it off himself.

[JoeyQ]

Hi All!
Wanted to give you an update on Joey! He is doing great in our new home and almost immediately upon arrival. There must have been something that changed in our apartment where he had suddenly developed so many problems. I did consult with a behaviorist while still in our apartment which helped me. He is now 12 and seems to have some increasing anxiety when we leave but behaves himself, uncrated, pretty well after we leave... a few times he has torn apart some papers but those were left as bait if he needed some release. He recovered from his tooth extractions. Thanks again for your interest and assistance! This is a great forum!
Joey's Mom

[Chelsea-BasenjiChi]

So glad to hear the move into your new house has Joey all settled & Happy!

[JoeyQ]

Thank you! I wasn't going to give up on him!

[YodelMa]

I have been wondering how Joey is doing--so glad he's doing well! Did you ever try Clomicalm? Should the need ever arise again, Trazadone is a very benign anti-depressant; It's used in elderly humans with heart conditions and has a pronounced calming/somewhat sedative effect.

For anyone following the thread, Clomicalm is a re-patented version of clomipramine, an old tricyclic antidepressant. It is sold considerably cheaper for humans as Anafranil. It is an old tricyclic anti-depressant, seldom used in humans nowadays because of potential liver toxicity. In my opinion at best it's an ineffective cash grab, at worst it's dangerous. I would steer clear--there are much safer, more modern SSRI's available.

[JoeyQ]

I did try Clomicalm but I don't think he was on it long enough or his anxiety level was too strong to see a change.
He may have been in pain that I did not detect. I just never found a definitive cause. Sure wish they could talk sometimes!

[JoeyQ]

@yodelma said in Major behavior change after 10 years!! Help!:

opinion

I'll keep Trazadone in mind for the future. He is managing pretty well for now.

[JoeyQ]

Saw a new vet today for a check up...she suggested trying Prozac to treat situational anxiety. Thoughts?

[DebraDownSouth]

Prozac made a big difference in Cara.

[Rocky1]

Prozac was a factor in the death of my beloved Thunder. Yes, it did work but the price both him and me paid was high. This happened back in 2003 and to this day I mourn for him.

Kathryn

[DebraDownSouth]

@rocky1 ...as i
I wrote in 2016...I am sorry about your dog, but it's rare. Other drugs may be more dangerous and far less researched.

DebraDownSouth Aug 28, 2016, 11:18 PM reply quote
Rocky1, I am sorry about your dog, and absolutely liver is a KNOWN side effect, albeit small, with the drug. So anyone doubting you needs to do some research.

However, your other information is a not accurate.

first, no, clomicalm is not the doggy form of prozac.

Second, 5-htp has toxicity also. Almost no drug comes without risks. http://www.ncbi.nlm.nih.gov/pubmed/10863592
Add to the fact that prozac has been used and researched heavily, whereas research on 5-HTP is scarce in humans and almost nonexistent in dogs beyond the toxicity above. "natural" doesn't mean safe.
http://psychology.wikia.com/wiki/Hydroxytryptophan_(5-)

In humans it also can cause liver damage

Tryptophan use has been associated with the development of serious conditions, such as liver and brain toxicity, and with eosinophilic myalgia syndrome (EMS), a potentially fatal disorder that affects the skin, blood, muscles, and organs (see "Overview" section). Such reports prompted the FDA to ban the sale of all tryptophan supplements in 1989. As with tryptophan, EMS has been reported in 10 people taking 5-HTP.
Side effects of 5-HTP are generally mild and may include nausea, heartburn, gas, feelings of fullness, and rumbling sensations in some people. At high doses, serotonin syndrome, a dangerous condition caused by too much serotonin in the body, could develop. Talk to your health care provider before taking higher-than-recommended doses.
People with high blood pressure or diabetes should talk to their doctor before taking 5-HTP.
If you take antidepressants, you should not take 5-HTP (see "Possible Interactions" section).
People with liver disease, pregnant women, and women who are breastfeeding should not take 5-HTP.<<

Clomicalm (clomipramine hydrochloride) is a tricyclic antidepressant and affects chemicals in the brain (serotonin)
Prozac, fluoxetine, is a selective serotonin reuptake inhibitor (SSRI) antidepressant drug . Its FDA-approved veterinary formulation is known as Reconcile.

Clomicalm slows the reabsorption rate of the neurotransmitters serotonin and norepinephrine, allowing their levels to rise in the brain. This drug is mainly used to treat separation anxiety. Prozac, on the other hand, works by strongly blocking the reabsorption of serotonin allowing more serotonin to be available for extended periods of time.
http://www.ehow.com/info_12227764_difference-between-clomicalm-prozac-dogs.html

http://www.ncbi.nlm.nih.gov/pubmed/10863592

Prozac, clomicalm and 5-HTP can all cause liver issues.

Debra<<<<<

[JoeyQ]

@rocky1 I'm so very sorry for your loss. They become such a part of our souls. I've already had a few tears over just the thought of what it will be like without him.