We are currently in the middle of a Spring Break road trip with Nicky, 9, Rally, 6, Rio, 2, and Sophie, 17 weeks. We are doing pretty well. The first leg of the trip was a 10 hour drive to Las Vegas. We try to stop about every 3 hours. They all did well our four days in Vegas. I would recommend taking the pups back out right after they have had a chance to explore the room. It seems to be exciting enough to work Sophie up enough to pee. The next leg of the trip was about 4.5 hours to Irvine. We stopped a little before the half way point at about 2 hours. That seemed fine with them since it was warm in the desert and they didn't really want to spend to much time out of the air conditioned car. Today after an hour run at the dog beach we took a small trip down the coast to San Diego. So far so good. Thursday will be the return trip which will be another long drive but they should be quite happy to see home.