I dont know if it will help however you might try this:
you and your friend and Tayda all sit in a room when you get back. Give your friend lots of treats and everytime she makes nice with her, give her a treat. if she does not and growls or anything have her turn her back to her and you dont give her any attention either. It may take a while if it will work but its worth a chance. The only other thing i can think about it maybe the vet clinic, as others have already stated. Good luck and sorry to hear 
Yes, definitely 3 weeks is way too long for Tayda to not be getting her pills - I would not even entertain that for half a millisecond. I suppose at least at the vets kennel she and Lenny will still be together, but (sigh) I hate to think about them being in a strange place for so long.
We've had a total of 5 people over the last couple years staying at the house to watch them and pill Tayda and this has never happened…. and of all the people staying at the house, this friend is the one that she actually has been around the most. So it's really strange....
I suppose we'll see how it goes this morning, she was going to just try to be friendly with Tayda for the rest of yesterday evening and give her lots of treats and praise and then see if she could pill her in the morning. My husband will be home around noon today so she'll get her pills then by the latest.
Sigh... I wish I could just explain to Tayda how all of this works and tell her that if she acts like this she'll have to be in the scary kennel for THREE WEEKS. BLAH!
If this is someone that Tayda has felt comfortable with, there might be something that is making her feel cranky. Maybe a UTI? A tooth problem? You may not have time to repair the relationship before your trip, but I am sure that eventually it can be repaired. Is it possible that you could have someone else (maybe pay a vet tech that the dogs approve of?) to stay with them while you are gone? I am sure your friend has good dog skills, but sometimes it takes a professional to deal with the most challenging customers 
Or maybe just a change in the person trying to do the pilling would be enough for Tayda to accept it…she may just be done with this person for a while, if she accidentally hurt her, or whatever.
When was the last time that Tayda had her Vet Check up? Could she plain not feel well and not into dealing with a "mostly" stranger?… and the pilling part?
Is there anything different about this person from the last time when Tayda was OK with her?... A change in perfume?... Medications?.....
The only thing I could add is perhaps have your sitter or someone go take her out to play each day so she gets attention and makes the vet's office less stressful. Or, work on making them get along as suggested, keep the kennel apt with the understanding you pay for the spot and the sitter will take her there if she can't get her to take the pills.
or, if the vet isn't too far…or A vet isn't too far....and Tayda and housesitter can be friends, the housesitter can take to the vet am/pm just for pilling? you could pay everybody a little extra for the piece of mind?
Good idea Andrea!
That really is the best idea, after the vet visit, the pet sitter can take her and do something "fun" for her..walk in a new area, buy her a bit of ice cream, something like that…
thanks for the suggestions everyone. Apparently after an evening of ignoring tayda she came around and slept on the bed with our friend, and then this morning's pilling went smoothly. The kennel is about an hour away from where I live so it's not all that convenient. But I will try to find a vet tech around here that could pill her just in case….
i think if you decide to have the petsitter come stay in your house, i'd look into the DAP for that time period. can't hurt (doesn't mean pilling will go smoothly, but i think it would improve a bit of grumpiness)
When was the last time that Tayda had her Vet Check up? Could she plain not feel well and not into dealing with a "mostly" stranger?… and the pilling part?
Is there anything different about this person from the last time when Tayda was OK with her?... A change in perfume?... Medications?.....
Her last set of blood work was about a month ago - her blood gases were right on and her blood chemistries were showing slightly elevated phosphorus so we eliminated the pet cal from her protocol. I want to get her in for another set of blood chemistries because since that appointment, in addition to removing the pet cal, I have started making her a homemade diet - which she LOVES. I got some great guidance from another Fanconi B owner/breeder off the yahoo group to balance her protein/calcium/phosphorus. She is up to 18 lbs now! She was hovering around 14-15 lbs which was just too skinny, even for her petite frame. At 18 lbs she looks very healthy. yay!
Have you considered having the pet sitter stay with you for a few days or even a week before you leave, doing what he/she normally would do with the dog or dogs while you are there also?
With most dogs, it's just the change in routine that is upsetting. Tucker likes things to have things be the same all the time and even the smallest change can start a spiteful peeing spree, some unusual growling and other things.
We used to get a housesitter/petsitter to com stay at our condo when we still lived there and EVERY time when we got home we would find pee somewhere in the house and Tucker would pee in the house for days after, sometime weeks. Tucker did okay at the kennel, but after 3-4 days, he becomes incorigable even to the trained staff there. My stepfather passed several years ago right at the end of my alumni reunion weekend. Wife and I were in Charleston, had spent the weekend there and got the call as we were leaving town and had to divert to Greenville rather than home. We were away for 10 days and around day 6 or 7, Tucker started biting the staff back home at the kennel…
