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Cushings Disease

Basenji Health Issues & Questions

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    Here is the test information that Missy had done and an article with the portion that includes Melatonin for treatment. I have inlcuded the webpage for the entire article. She has not been on the Melatonin long and I am slowly increasing her dosage but she is definitely not as puffy in the intestinal area as she was. The Adrenal Panel with Combined Dex Supp/ACTH Stim Test for Dogs: The following hormones are tested in the adrenal panel: Cortisol, Estradiol, Androstenedione, 17-Hydroxyprogesterone, Progesterone and Aldosterone. REVIEW ARTICLES Steroid Profiles in the Diagnosis of Canine Adrenal Disorders Jack W. Oliver, Proceedings 25th ACVIM Forum, Pp. 471-473, Seattle, WA. 2007. http://www.vet.utk.edu/diagnostic/endocrinology/pdf/Steroids%20Profiles%20in%20the%20Diagnosis%20of%20.doc Melatonin. Results of in vitro cell culture (human H295R adrenocortical carcinoma cells) studies in our lab55 revealed that both 21-hydroxylase and aromatase enzymes were inhibited by melatonin. Also, in dogs with adrenal disease that are treated with melatonin, and repeat adrenal steroid panels are done, cortisol levels are consistently reduced, and estradiol levels are variably reduced.29 Inhibition of the 21-hydroxylase enzyme would lower cortisol levels, and inhibition of the aromatase enzyme would lower estradiol levels. Estradiol levels were decreased in a prior study of dogs treated with melatonin.31 Results of in vitro studies with human MCF-7 breast cancer cells also revealed that melatonin inhibited aromatase enzyme, which resulted in reduced estradiol levels.56 Melatonin treatment for cases of mild adrenal disease in dogs may be effective, and particularly in cases where sex steroids are increased. Jennifer
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    I haven't had a lot of experience with it. But I am researching it because I think the Boxenji has it, and, for those interested, here are some items about Cushing's Disease. There are different types of Cushing's as follows. Pituitary Dependant Hyperadrenocorticism-Most common Adrenal-based Hyperadrenocorticism Iatrogenic Hyperadrenocorticism The most common symptoms include: • increased/excessive water consumption (polydipsia) • increased/excessive urination (polyuria) • urinary accidents in previously housetrained dogs • increased/excessive appetite (polyphagia) • appearance of food stealing/guarding, begging, trash dumping, etc. • sagging, bloated, pot-bellied appearance • weight gain or its appearance, due to fat redistribution • loss of muscle mass, giving the appearance of weight loss • bony, skull-like appearance of head • exercise intolerance, lethargy, general or hind-leg weakness • new reluctance to jump on furniture or people • excess panting, seeking cool surfaces to rest on • symmetrically thinning hair or baldness (alopecia) on torso • other coat changes like dullness, dryness • slow regrowth of hair after clipping • thin, wrinkled, fragile, and/or darkly pigmented skin • easily damaged/bruised skin that heals slowly • hard, calcified lumps in the skin (calcinosis cutis) • susceptibility to infections (especially skin and urinary) • diabetes, pancreatitis, seizures There are three tests they use to diagnose Cushings-depending on what type of cushings they have. Either there is too much cortisol or too little in the blood. Urine Cortisol/Creatinine Ratio Test ACTH Stimulation Test Low Dose Dexamethasone Suppression Test High Dose Dexamethasone Suppression Test The high dose test is generally used as to diagnose which type of cushings the dog has. The low dose test is the one generally used to diagnose that the dog has cushings and is said to be about 90-95% accurate in diagnosing.
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    Yea my vet told me that during our last appointment. He said not to let Dallas sniff other dogs poop no matter where we are because the poop can contain diseases. I see poop all around our community because people don't pick it up after their dogs but Dallas [so far] never really gets too near ti that I have to pull him away.
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    keep us posted with the progress….