Fanconi in pups of "clear" parents?

[tanza]

@eva:

What I am saying is the current test we have is a linked marker test. It is a very valuable first step and is the result of many hours of research. It is not a direct test as the gene that actually carries fanconi has yet to be identified. Responsible and Reputable breeders and owners will do their part by first having their dogs tested. Then since fanconi is a late onset disease should continue to strip test their dogs regardless of the results they receive for several years and report any inconsistent results so those dogs DNA can be further studied and hopefully bring the researchers closer to problem gene. Sir we are only 3 years into this portion of the battle. There are many dogs who are way younger than the typical age of onset and errors are being reported. There are carriers that have developed fanconi, there are puppies being tested affected from clear parents. There are old dogs that tested affected that have never displayed the disease.

What puppies from Clear Parents are testing affected? Not in data that I have seen? And puppies that are testing affected, have the sire and dam's been retested? And is there any questions about their parentage? The two that I know (puppies testing affected), one was from an admitted sample mix up taken at the 2007 BCOA National when blood was still being used and there were a number of dogs that had to be retested from that time. The other that I know of, turns out there was a question on if the sire/dam were really the parents of that puppy.

While I do not disagree with your about strip testing and that this is a linkage test and as you point out has only been available for coming close to 4yrs so the data is still being collected.

[angelinahotty]

what do i use to test my basenji? also any information would be helpful…i have read alot, but would rely on people that know about basenjis.....my basenji's mother was fanconi positive and now the vet says she wants to do all these expensive test.....and my girl is only two years old and has no health issues at all since her spay in march.......any info would me appreciated.

[DebraDownSouth]

What do you mean fanconi positive? She was tested and the results were probable affected or probable carrier, or she is spilling urine?

You need to strip test your dog and your mother's (if she hasn't already developed Fanconi) every month, preferably a couple of days in a row, with urine test strips.

You need to order from OFA the fanconi cheek swab kit ($65 each) and submit.
http://www.offa.org/dnatesting/fanconi.html

You need to read ALL these links:
http://www.basenjicompanions.org/health/fanconi/index.html

Please clarify the info on your mom's dog so we can help. If YOUR dog from your mom's? Has she spayed her dog and notified everyone who has a puppy from this bitch (if she bred her) that Fanconi is a problem? Please have her share all the above with them if she did breed her.

[angelinahotty]

No, i mean my dog's mother is fanconi positive, she isnt spilling urine….the mother is 8 years old......all i know is the breeder(which has stopped breeding) called me and told me that my basenji's mother is fanconi positive. so basically, what i need to know is what does that mean for my girl. she shows no signs, is there anything i need to be doing? i will read the links.....thank you for the info.

[Rivermoon]

Yes, you need to clarify some of the info you gave…but even without that info, as Debra said, you should be strip testing your pup. There's no need to have your vet do any tests on her at this time BUT, you should be sending in the swab to find out what the linked marker test says. Regardless of what it does say, you should still strip test, but at least you'll have a better idea.

I started strip testing Apache right after he came back as Probably Affected, which was a month before his 2nd birthday. I strip tested him once a week at first and then when he hit 3 I did it weekly but did it a few days in a row at different times. When I did catch him spilling, just last month, he was spilling in the morning and early afternoon but not later in the afternoon or in the evening. At first I thought I was seeing things or that I somehow contaminated the strip. I had my husband come out and watch the second time..it changed again. Then I went and peed on one and it didn't change, so I knew then it wasn't that the strips were bad and I got him into the vet for all his tests.
They will spill sporadically at first which is why it's best to test a few days in a row and at different times of the day.

I have to admit to becoming a little lax with testing Cheyenne, who is a probable carrier, but since hearing of those that came back as carriers and are now affected, I've started testing her weekly now too.

[angelinahotty]

thank you so much i am on it!!! i am gonna do everything i can to keep my girl taken care of….i really appreciate the info.

[dcmclcm4]

It is not spilling urine but spilling glucose in the urine. How was the mother diagnosed as being Fanconi Positive? Was it from the DNA test sent to the Univ. of MO or a urine glucose strip? Has the father been tested?

Jennifer

[Terry]

I think she meant the dam of her girl was Fanconi positive, not her mother's dog. But yes, it would help to know what she meant when she said positive.

Terry

[Terry]

Oops, when I hit post, the other responses came up, and I see angelinahotty already clariified.

Terry

[DebraDownSouth]

Okay sorry, I misread "basenji's mother" for mother's basenji.

Do you have your dog's registration number? If so, you can look up to see if the sire has been tested. If the dog is probable clear, your chances are good that your dog may never develop Fanconi. If the dog is a probable carrier or probable affected, then the chances are much worse.

The mother has only 2 genes to pass, both Fanconi.
If the sire is a probable carrier, then your chances for your dog to be affected are 50 percent and 50 percent chance probable carrier.
If the sire is affected, then your dog will be a probable affected. That does not mean 100 percent develop the disease.

Although the protocol calls for MONTHLY, not weekly testing, I can understand Lynn testing weekly with a probable affected. But at the very least, do monthly a couple of days in a row.

[angelinahotty]

the breeder said her mother(the dogs mother) is dna positive..and also her grandmother….the father(the dogs father) is deceased ....i meant spilling glucose. please bear with me because i am new to this and learning what i need to be doing. i had no idea when i bought her that i needed to ask about these things...which makes no difference to me now considering i love her to death.....now i just have to take care of her.....like i said there have been no signs....she is perfectly healthy,utd on everything , i just want to keep her that way.thank you again for the info.

[angelinahotty]

i will look her numbers up…thank you for the info

[angelinahotty]

the breeder was a friend of my family and only had like 4 litters, he wasnt very experienced, but the dogs were registered. i really dont think he knows very much either,….but i am going to go digging into her registration info and family tree and see what i can find. like i said, she shows no signs, but you know what they say about prevention..... thank you all

[Salis]

Just today I've got the results of my basenji. She is carrier. But her parents are both clear. I expected another resuls by the way…

[JoT]

@Salis:

Just today I've got the results of my basenji. She is carrier. But her parents are both clear. I expected another resuls by the way…

Salis,
Please contact Liz Hansen at the research lab and inform her of this situation. She will need the full names of your dog and both parents. Please send her an email at : HansenL@missouri.edu,

Liz is very nice and quite helpful. She will help you understand the results. She will investigate your test.

[Salis]

@JoT:

Salis,
Please contact Liz Hansen at the research lab and inform her of this situation. She will need the full names of your dog and both parents. Please send her an email at : HansenL@missouri.edu,

Liz is very nice and quite helpful. She will help you understand the results. She will investigate your test.

JoT, thank you! I've already wrote Liz Hansen:-)

I'm a bit unlucky with it test, i made order in January and after half a year I got this result! Lucky it's not affected!