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  3. Major behavior change after 10 years!! Help!

Major behavior change after 10 years!! Help!

Behavioral Issues
  • DebraDownSouthD

    @rocky1 ...as i
    I wrote in 2016...I am sorry about your dog, but it's rare. Other drugs may be more dangerous and far less researched.

    DebraDownSouth Aug 28, 2016, 11:18 PM reply quote
    Rocky1, I am sorry about your dog, and absolutely liver is a KNOWN side effect, albeit small, with the drug. So anyone doubting you needs to do some research.

    However, your other information is a not accurate.

    first, no, clomicalm is not the doggy form of prozac.

    Second, 5-htp has toxicity also. Almost no drug comes without risks. http://www.ncbi.nlm.nih.gov/pubmed/10863592
    Add to the fact that prozac has been used and researched heavily, whereas research on 5-HTP is scarce in humans and almost nonexistent in dogs beyond the toxicity above. "natural" doesn't mean safe.
    http://psychology.wikia.com/wiki/Hydroxytryptophan_(5-)

    In humans it also can cause liver damage

    Tryptophan use has been associated with the development of serious conditions, such as liver and brain toxicity, and with eosinophilic myalgia syndrome (EMS), a potentially fatal disorder that affects the skin, blood, muscles, and organs (see "Overview" section). Such reports prompted the FDA to ban the sale of all tryptophan supplements in 1989. As with tryptophan, EMS has been reported in 10 people taking 5-HTP.
    Side effects of 5-HTP are generally mild and may include nausea, heartburn, gas, feelings of fullness, and rumbling sensations in some people. At high doses, serotonin syndrome, a dangerous condition caused by too much serotonin in the body, could develop. Talk to your health care provider before taking higher-than-recommended doses.
    People with high blood pressure or diabetes should talk to their doctor before taking 5-HTP.
    If you take antidepressants, you should not take 5-HTP (see "Possible Interactions" section).
    People with liver disease, pregnant women, and women who are breastfeeding should not take 5-HTP.<<

    Clomicalm (clomipramine hydrochloride) is a tricyclic antidepressant and affects chemicals in the brain (serotonin)
    Prozac, fluoxetine, is a selective serotonin reuptake inhibitor (SSRI) antidepressant drug . Its FDA-approved veterinary formulation is known as Reconcile.

    Clomicalm slows the reabsorption rate of the neurotransmitters serotonin and norepinephrine, allowing their levels to rise in the brain. This drug is mainly used to treat separation anxiety. Prozac, on the other hand, works by strongly blocking the reabsorption of serotonin allowing more serotonin to be available for extended periods of time.
    http://www.ehow.com/info_12227764_difference-between-clomicalm-prozac-dogs.html

    http://www.ncbi.nlm.nih.gov/pubmed/10863592

    Prozac, clomicalm and 5-HTP can all cause liver issues.

    Debra<<<<<

    Debra

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  • J

    @rocky1 I'm so very sorry for your loss. They become such a part of our souls. I've already had a few tears over just the thought of what it will be like without him.

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    @LBRunyon: I have a supplementary question along these same lines . We got our BRAT Ricky two weeks ago ( YIPPEE!!!! ) He is WONDERFUL . The only problem we are having is that he WILL NOT potty in our fenced in yard . In fact , it seems he won't go within 1 block of our house . We walk in the am and pm . He is very particular about where he will go, though he sniffs every available surface . While the weather is nice , I really don't mind this . We would be walking anyway . But when the frigid cold hits , it would be nice to open the door and have him go out , do his business quickly , and return . We have tried waiting him out in hopes of praise and treats once he goes in the yard . But Mr. iron- bladder- steel- sphincter WON'T go in the yard. Are there any suggestions ?Oh , by the way, once we are out of the yard and down the street he goes after a few quick sniffs . I have to take my B outside no matter what. It's nice during the spring/summer/fall, but the midst of winter is just simply brutal. -20F with a nice wind (colder windchill) will make any B go quickly, but it's still painful for us humans.
  • wizardW

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  • U

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    Thanks guys! I will be checking those books out!