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DNA testing for Pyruvate Kinase Deficiency…

Basenji Health Issues & Questions
  • I am getting myself organised to continue with my health testing, of Ochre and Saba. Saba is booked in this week to get his Hips/Elbows done, and he has already had his Fanconi done. Ochre is about to have her cheek swab done for Fanconi, just waiting to hear back from Genetic Technologies re that…

    When I got some documentation from this company, it has a list of all the diseases that can be DNA tested for all the different breeds. Listed under the Basenji was Pyruvate Kinase Deficiency, (PK). (Interesting that Fanconi wasnt listed either :confused:)This stumped me as I had not heard of this disease in relation to the Basenji...

    Is this something that should be routinely tested for ??? I will be doing some "homework", in relation to this disease, but Im just interested in people's thoughts :) Do I need to get it done ???

  • PK testing is for Hemolytic Anemia, mostly not seen in Basenjis today. Like Fanconi it is a recessive gene…. you can read about it at www.basenji.org or www.basenjihealth.org and it was a big problem 30 yrs ago (I may be wrong on the date.. it was before my time in Basenjis)

  • Thanks Tanza :).

    Well you can see that I didnt do my homework on this disease BEFORE I posted my question :o:o.

    (Says this, then runs off to commence my edumacation for the day. Topic is… H.A. :))

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    Ooops - But I do think it would be fun to get the results. Thanks Nicola for doing this thread - It's quite interesting.
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    They should be both equally as accurate, but you just have to make sure that the dog hasn't eaten anything that was alive for a MINIMUM of an hour before the cheek swab, while it doesn't really matter for the blood test.
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    @wizard: I've looked at that website but still don't understand the reason behind doing this test. It doesn't check for genetic defects just parentage. It seems it undeniably verifies parentage, but isn't that what the AKC registration does? There must be something I'm missing. It is to prove parentage… as you could put any name of any dog on a set of papers and sent them it.... which in cases of Puppy Millers and some BYB's that is was was being done..... so the parents were NOT the parents of a given puppy. If you read the minutes each month on the AKC site (Secretary's page) you can see how many litter registrations were reversed "due" to DNA parentage.
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    @etzbseder: Thanks, I've seen that before, but forgot about it. After looking at that, it shows that my answer would be: Clear pups ONLY means that neither parent is affected, and that does not change with multiple clear pups. The only thing that shows any determination of the parents is a test of the parent themselves (or if their grandparents are clear). correct. The more clear pups (with no affecteds or carriers) you had from the breeding of the same two animals, the more LIKELY it is that the parents are clear…but it certainly would not be a for sure.
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    @Mia: I don't know who her grandparents are, how would I find that out (website)? I have the registration #'s for both her parents. You can order a pedigree from AKC, www.akc.org and then go to the store link. You can order it on line as an electronic file for 10.00. Most breeders give you an extended pedigree?