Cooper started shots this spring to desensitize him to dust mites and storage mites. He's severely allergic to both (we cleaned out a closet and one room in preparation for our move, and he's still covered in hives a week later!).
He did really well through his first ramp-up vial, but we're nowhere near maintenance level yet. We've had a few setbacks, but we're optimistic (my husband has been on allergy shots for half his life and they make life bearable!).
Be sure AHEAD OF TIME to ask your vet what to do if/when you hit your dog's threshold before reaching maintenance. How to step back a level, whether to give antihistamines and/or steroids, or to use any topical treatments.
So far, it's been relatively cheap (we're still on our first set of serum), and we think we've figured out Cooper's dosing schedule.
Also, as with any new experience, use treats! Cooper now sits automatically when he sees a syringe. At my parents' house, he always gets a treat for sitting quietly while my dad injects insulin. Now, he knows he gets chicken chips during and after his shot! But it takes my husband holding the treat and me handling the shot.
Hope this helps.
I'd be interested in hearing about other B allergy stories. We supplement with omega fatty acids, use ProPlan sensitive skin and stomach, use the mildest shampoos and conditioners recommended by our groomer, use Benadryl, and are constantly trying to wean him from prednisone.