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Early detection of Kidney Disease

Basenji Health Issues & Questions

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DebraDownSouth
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IDEXX Test Detects Kidney Disease
https://www.idexx.com/corporate/news-and-events/press-release/2015/20150119pr.html

Someone mentioned this test, but I don't remember who. However, I talked to a couple of vet and vet techs who say they recommend it any time you have kidney issues in the line, or an individual pet has "off" blood work. As my friend and tech said "SDMA isn't the whole picture, but it is a piece of the puzzle. Our hands are usually tied by finances but regular scanning blood work is a pets best friend"

If the SDMA is elevated, she said they know to start close kidney monitoring.
Debra
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• • • camlich

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I am SO sorry for what you and your sweet boy went through. My heart broke just reading it. I know he could feel your love and knew you were doing everything to take good care of him. God bless you and your Cassius.
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• • • zurisbode

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Yes, my Naomi had Cushing’s. You will need to work with your veterinarian for the best treatment.
Lysodren was the first drug we tried. Trilostane was the drug that really worked for her. She regained her muscle tone and she strength and brightened back up.

She did very well. She had her ACTH tested regularly, sitting quietly and patiently in the waiting room with me as she never liked the kennels at the veterinarian’s and threw unending basenji fits.

I do remember the first signs of Cushing’s. Naomi’s tail developed a strange kink. None of the veterinarians in the practice could find anything wrong with her tail. She was otherwise healthy and bright.
Next, she dropped a bar in agility. She never touched a jump before that, and could of course, jump much higher than her designated jump height.
It did take a while for her to get to the point where she could be diagnosed.

Naomi fought inflammatory bowel syndrome for a good part of her life. She often had bad tummy days. We did the best we could to keep her comfortable and happy. In the end, a tumor was detected in her bowel, and we made the difficult decision to euthanize.

I don’t know how long she would have lived on the Trilostane protocol. She was a darling, beautiful little dog, and I miss her greatly.

I do wish you the greatest of luck with your baby, and pray that your sweet pup and you have many, happy, healthy years ahead of you.
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Early Kidney Disease - Difficulty Getting Her to Eat

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• • • imbj

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One of my Basenjis is also diagnosed with early kidney disease. The vet prescribed Enalapril Maleate (generic for Vasotec). My vet allowed me to choose whatever prescription food I wanted to use. After some research I chose Blue Buffalo BLUE Natural Veterinary Diet KS Kidney Support. I looked into and tried a more holistic food, Dr. Harvey's - a dehydrated food, but Kushika couldn't manage to eat it without getting it all over the walls, kitchen floor, and herself so we went back to the kibble. I liked the Dr. Harvey food AND you can call to talk to Dr. Harvey, who asked me to send Kushika's lab results to him so he could make specific recommendations dependent on those results. Kushika came to live with us at almost 10 years old and was immediately diagnosed with kidney disease. At age 12+ she is still with us, going strong and looking better than when she arrived.
Q

Vestibular disease and Stroke. Please help!

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• • • quekong

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We had a Dalmatian that started having these issues at the same age as your B. Vestibular disease got worse causing her to lose her balance and fall when walking, loss of strength in her hindquarters and incontinence. I am not aware of any treatments for the VD, but there are a number of human treatments for strokes that might be able to be used in dogs.
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• • • dcmclcm4

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Here is the test information that Missy had done and an article with the portion that includes Melatonin for treatment. I have inlcuded the webpage for the entire article. She has not been on the Melatonin long and I am slowly increasing her dosage but she is definitely not as puffy in the intestinal area as she was.

The Adrenal Panel with Combined Dex Supp/ACTH Stim Test for Dogs:

The following hormones are tested in the adrenal panel: Cortisol, Estradiol, Androstenedione, 17-Hydroxyprogesterone, Progesterone and Aldosterone.

REVIEW ARTICLES
Steroid Profiles in the Diagnosis of Canine Adrenal Disorders
Jack W. Oliver, Proceedings 25th ACVIM Forum, Pp. 471-473, Seattle, WA. 2007.

http://www.vet.utk.edu/diagnostic/endocrinology/pdf/Steroids%20Profiles%20in%20the%20Diagnosis%20of%20.doc

Melatonin. Results of in vitro cell culture (human H295R adrenocortical carcinoma cells) studies in our lab55 revealed that both 21-hydroxylase and aromatase enzymes were inhibited by melatonin. Also, in dogs with adrenal disease that are treated with melatonin, and repeat adrenal steroid panels are done, cortisol levels are consistently reduced, and estradiol levels are variably reduced.29 Inhibition of the 21-hydroxylase enzyme would lower cortisol levels, and inhibition of the aromatase enzyme would lower estradiol levels. Estradiol levels were decreased in a prior study of dogs treated with melatonin.31 Results of in vitro studies with human MCF-7 breast cancer cells also revealed that melatonin inhibited aromatase enzyme, which resulted in reduced estradiol levels.56 Melatonin treatment for cases of mild adrenal disease in dogs may be effective, and particularly in cases where sex steroids are increased.

Jennifer
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keep us posted with the progress….

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Early detection of Kidney Disease

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