I used to use Frontline/Advantage on my males (both over the bridge now) but my female is super sensitive. These meds burned off her fur where applied!
Now I use an herbal flea/tick spray made with citronella but it has to be sprayed (lightly will do) on her every day. I discovered, quite by accident, that it will kill fleas instantly. She caught a rabbit the other day and of course the fleas jumped ship and immediately started biting her - as soon as I sprayed she had relief.